Remick began her career on stage and TV in the 1950s and continued to appear in both media through the late 1980s. She received a Tony nomination for her most famous Broadway role, as the blind woman menaced by three criminals in Frederick Knott's 1966 thriller "Wait Until Dark". Her sophisticated elegance made her well suited for Stephen Sondheim musicals: she starred on Broadway in his short-lived "Anyone Can Whistle" (1964); as the sassy former showgirl Phyllis in a concert version of "Follies" (PBS, 1986); and as the glamorous actress Desiree in a 1991 Los Angeles production of his "A Little Night Music", from which she withdrew due to a relapse of cancer.
Beginning in the 70s, Remick worked increasingly in TV, becoming the queen of reality-based TV-movies and miniseries. She gave memorable performances as Jennie Jerome in "Jennie: Lady Randolph Churchill" (1975); as Kay Summersby in "Ike: The War Years" (1979); as Margaret Sullavan in "Haywire" (1980); and as the scheming socialite Frances Bradshaw Schreuder in "Nutcracker: Money, Madness, and Murder" (1987).